(2025)
- Keanu Reeves - Johnny Mnemonic
- Dina Meyer - Jane
- Takeshi Kitano - Takahashi
- Ice-T - J-Bone
- Dolph Lundgren - Street Preacher
- Denis Akiyama - Shinji
- Henry Rollins - Spider
- Barbara Sukowa - Anna Kalmann
- Udo Kier - Ralfi
- Tracy Tweed - Pretty
- Falconer Abraham - Yomamma
- Don Francks - Hooky
- Diego Chambers - Henson
- Sherry Miller - Takahashi's Secretary
- Arthur Eng - Viet
- Von Flores - Viet
- Victoria Tengelis - Pharmakom Receptionist
- Warren Sulatycky - Yakuza Operator
- Celina Wu - Mikiyo
- Jamie Elman - Toad
- Simon Sinn - Man in Hotel Lobby
- Caitlin Carmody - Twin in Hotel Lobby
- Erin Carmody - Twin in Hotel Lobby
- Douglas O'Keeffe - Pharmakom Security Officer
- Marlow Vella - Lotek Kid
- Howard Szafer - Strike
- Paul Brogren - Stump
- Arthi Sambasivan - Nurse
- Michael A. Miranda - Stick
- Coyote Shivers - Buddy
- Lynne Adams - Yakuza with Rocket Launcher
- Michael Shearer - Yakuza Partner
- Susan Tsagkaris - Opera Singer
- Chris Comrie - Beijing Riot Newscaster
- Gene Mack - Laslo
- Robin Crosby - Girl in Hotel Room
- Glenn Bang - Bandleader (uncredited)
- Natalie Gray - Tall Chinese Man (uncredited)